Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA
R Nanjunda, EA Owens, L Mickelson… - Bioorganic & medicinal …, 2012 - Elsevier
Design and optimization of quadruplex-specific small molecules is developing into an
attractive strategy for anti-cancer therapeutics with some promising candidates in clinical …
attractive strategy for anti-cancer therapeutics with some promising candidates in clinical …
Second generation G-quadruplex stabilizing trimethine cyanines
EA Owens, HT Huynh, EM Stroeva… - Bioconjugate …, 2019 - ACS Publications
G-Quadruplex DNA has been recognized as a highly appealing target for the development
of new selective chemotherapeutics, which could result in markedly reduced toxicity toward …
of new selective chemotherapeutics, which could result in markedly reduced toxicity toward …
Selective G-quadruplex DNA recognition by a new class of designed cyanines
A variety of cyanines provide versatile and sensitive agents acting as DNA stains and
sensors and have been structurally modified to bind in the DNA minor groove in a sequence …
sensors and have been structurally modified to bind in the DNA minor groove in a sequence …
Selenium-substituted monomethine cyanine dyes as selective G-quadruplex spectroscopic probes with theranostic potential
The binding interactions of six ligands, neutral and monocationic asymmetric monomethine
cyanine dyes comprising benzoselenazolyl moiety with duplex DNA and RNA and G …
cyanine dyes comprising benzoselenazolyl moiety with duplex DNA and RNA and G …
Selective recognition of G-quadruplexes by a dimeric carbocyanine dye
A novel dimeric carbocyanine dye is found to recognise G-quadruplex structures selectively
compared to mixed sequence or double-stranded DNA molecules. The dye exhibits a …
compared to mixed sequence or double-stranded DNA molecules. The dye exhibits a …
Multicharged phthalocyanines as selective ligands for G-quadruplex DNA structures
The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for
telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited …
telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited …
Recognition of G‐Quadruplex DNA by Triangular Star‐Shaped Compounds: With or Without Side Chains?
We report the synthesis of two new series of triangular aromatic platforms, either with three
aminoalkyl side chains (triazatrinaphthylene series, TrisK: six compounds), or without side …
aminoalkyl side chains (triazatrinaphthylene series, TrisK: six compounds), or without side …
A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA
G-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations,
serve important role in cancer cell growth and control gene expression in telomere. Since …
serve important role in cancer cell growth and control gene expression in telomere. Since …
Submicromolar, Selective G‐Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines
Ö Persil Çetinkol, AE Engelhart, RK Nanjunda… - …, 2008 - Wiley Online Library
The discovery of G-quadruplex structures in nucleic acid sequences associated with cancers
has created intense interest in Gquadruplexes as potential drug targets.[1] These …
has created intense interest in Gquadruplexes as potential drug targets.[1] These …
Targeting of parallel c-myc G-quadruplex by dimeric cyanine dye supramolecular assembly: dependence on the linker length
L Yu, Q Yang, J Xiang, H Sun, L Wang, Q Li, A Guan… - Analyst, 2015 - pubs.rsc.org
A series of dimeric cyanine dyes were designed to study their recognition for parallel c-myc
G-quadruplex as well as their spectral features in solution. Dimeric cyanine dyes having …
G-quadruplex as well as their spectral features in solution. Dimeric cyanine dyes having …