OBJECTIVES: The study aimed to characterize the pharmacokinetics (PK) of four β-lactams
(piperacillin, ceftazidime, cefepime, and meropenem) in patients comedicated with amikacin …

The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …

The pharmacokinetics of piperacillin were studied in a total of 26 Caucasian normal male
volunteers. Single intramuscular doses of 0.5, 1.0, and 2.0 g were given to three groups …

Background: The antibacterial effect of piperacillin/sulbactam depends on the time of drug
concentration above the minimal inhibitory concentration (MIC). Therefore, continuous …

Amikacin is commonly used for probabilistic antimicrobial therapy in critically ill patients with
sepsis. Its narrow therapeutic margin makes it challenging to determine the right individual …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Objectives To be effective, piperacillin/tazobactam (PTZ) unbound plasma levels need to be
above the minimum inhibitory concentration (MIC) at least 50% of the time between dosing …

This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …

Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …