Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

With increasing use of once-daily aminoglycoside dosing and renewed interest in
continuous infusions of p-lactam agents, there is a need to study the interaction between …

A better dosing strategy can improve clinical outcomes for patients. We systematically
reviewed the literatures to determine whether any clinical benefits exist for piperacillin …

Abstract Background and Objective Piperacillin/tazobactam is one of the most frequently
used antimicrobials in older adults. Using an opportunistic study design, we evaluated the …

The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …

Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam
in critically ill infants and children, in order to develop an evidence-based dosing regimen …

The pharmacokinetic characteristics of piperacillin sodium were studied in five volunteers
undergoing on-line hemodiafiltration (HDF). The subjects were given 2 g of piperacillin …

Methods: Blood samples (2–4 per child) were collected from 13 children ages 9 months to 6
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …

The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …

The aim of this study was to develop a population pharmacokinetic model for piperacillin
(PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the …