The p53‐inducible cyclin‐dependent kinase inhibitor, p21/WAF1/CIPI (p21), plays a pivotal
role in the G1 arrest or apoptosis of cells exposed to genotoxic stimuli. To determine whether …

The possibility that appropriately designed chemotherapy could act selectively against p53-
defective tumor cells was explored in MCF-7 human breast cancer cells. These cells were …

Mutations of the p53 tumor suppressor gene are the most common molecular genetic
abnormality to be described in ovarian cancer. To determine the feasibility of mutant p53 as …

It has been reported that overexpression of wild‐type p53 protein induces suppression of
tumor cell growth in vivo and in vitro. In this study, we further evaluated the differential effects …

The accumulation of molecular genetic defects selected during the adaptation process in the
development of cisplatin-resistance was studied using progressive cisplatin-resistant …

Inactivation of the cellular p53 gene is a common feature of Friend virus-induced murine
erythroleukemia cell lines and may represent a necessary step in the progression of this …

Prior reports suggest that p53 protein status may influence the response to gene
transduction with wild-type (wt) p53. Adenoviral vectors containing the p53 gene were …

Loss of functional p53 paradoxically results in either increased or decreased resistance to
chemotherapeutic drugs. The inconsistent relationship between p53 status and drug …

Drug resistance is one of the most important clinical problems in the treatment of ovarian
cancer. This study was designed to determine whether expression of p53 could be used as …

One of the mechanisms in which anticancer therapies function is to induce cell death by
apoptosis. In this regard, the biological activity of p53 may be critical since the presence of …