The application of gas chromatography-mass spectrometry (GC-MS) for the quantitative
analysis of endogenous compounds as well as drugs in clinical biochemistry is taken into …

The value of mass spectrometry äs an analytical technique lies in its potential for structural
and quantitative measurement, eg it combines the specific detection of a selected compound …

Publisher Summary This chapter discusses isotope dilution mass spectrometry in clinical
chemistry. Mass spectrometry (MS) in clinical chemistry is increasingly used as an analytical …

The isotope dilution method is characterized by the use of appropiately labelled standard
compounds in conjunction with mass spectrometry coupled to chromatographic systems …

The combination of gas chromatography and mass spectrometry enables the detection and
the quantitative analysis of various compounds. Isotope dilution mass spectrometry has …

The requirements for the quantitative analysis of organic substances in various biological
matrices continually emphasize lower limits of detection coupled with the preservation of …

Isotope dilution mass spectrometry is a technique that has been shown to be capable of
producing the accuracy and precision required of a reference method. The use of a labelled …

Several data reduction procedures have been used for converting isotope ratios, determined
using gas chromatography mass spectrometry, into mole ratios for the purpose of …

We report on the cooperation of two European Reference Laboratories for the determination
of reference method values in serum based materials intended for use in internal accuracy …

In recent years stable isotopes have begun to replace radioisotopes as tracers in metabolic
studies. However, these are relatively expensive in the enrichments and quantities required …