Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer

R Haq, DE Fisher - Journal of Clinical Oncology, 2011 - ascopubs.org
Members of the micropthalmia (MiT) family of transcription factors (MITF, TFE3, TFEB, and
TFEC) are physiologic regulators of cell growth, differentiation, and survival in several tissue …

The MiTF/TFE family of transcription factors: master regulators of organelle signaling, metabolism, and stress adaptation

L Slade, T Pulinilkunnil - Molecular Cancer Research, 2017 - AACR
The microphthalmia family (MITF, TFEB, TFE3, and TFEC) of transcription factors is
emerging as global regulators of cancer cell survival and energy metabolism, both through …

Melanocytes and the Microphthalmia Transcription Factor Network

E Steingrímsson, NG Copeland, NA Jenkins - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Emerging roles of the MiT/TFE factors in cancer

R Zoncu, RM Perera - Trends in Cancer, 2023 - cell.com
The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3,
MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject …

MITF—the first 25 years

CR Goding, H Arnheiter - Genes & development, 2019 - genesdev.cshlp.org
All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

TFE3 expression in tumors of the microphthalmia-associated transcription factor (MiTF) family

BC Dickson, JS Brooks, TL Pasha… - International Journal of …, 2011 - journals.sagepub.com
The DNA-binding factor TFE3 is closely related to microphthalmia-associated transcription
factor (MiTF) and is over-expressed in alveolar soft part sarcoma (ASPS) and select renal …

Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis

JA Martina, HI Diab, H Li, R Puertollano - Cellular and Molecular Life …, 2014 - Springer
The MiTF/TFE family of basic helix–loop–helix leucine zipper transcription factors includes
MITF, TFEB, TFE3, and TFEC. The involvement of some family members in the development …

MiT/TFE family of transcription factors, lysosomes, and cancer

RM Perera, C Di Malta, A Ballabio - Annual review of cancer …, 2019 - annualreviews.org
Cancer cells have an increased demand for energy sources to support accelerated rates of
growth. When nutrients become limiting, cancer cells may switch to nonconventional energy …

Micropthalmia transcription factor: a new prognostic marker in intermediate-thickness cutaneous malignant melanoma

GI Salti, T Manougian, M Farolan, A Shilkaitis… - Cancer research, 2000 - AACR
Micropthalmia transcription factor (Mitf) is involved in melanocyte development and
differentiation. The current study was undertaken to determine whether there is a …

Emerging roles and regulation of MiT/TFE transcriptional factors

M Yang, E Liu, L Tang, Y Lei, X Sun, J Hu… - Cell Communication and …, 2018 - Springer
The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and
lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are …