Objective Myostatin is an endogenous negative regulator of muscle growth and a novel
target for muscle diseases. We conducted a safety trial of a neutralizing antibody to …

Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the
absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous …

The elusive promise of myostatin inhibition for muscular dys... : Current Opinion in Neurology
The elusive promise of myostatin inhibition for muscular dystrophy : Current Opinion in …

Mutations in myostatin (GDF8) cause marked increases in muscle mass, suggesting that this
transforming growth factor‐β (TGF‐β) superfamily member negatively regulates muscle …

Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …

Myostatin is a highly conserved protein secreted primarily from skeletal muscle that can
potently suppress muscle growth. This ability to regulate skeletal muscle mass has sparked …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Myostatin, a TGF-β family member, is a negative regulator of muscle growth. Here, we
generated transgenic mice that expressed myostatin mutated at its cleavage site under the …

Key points Myostatin is an important regulator of muscle mass and a potential therapeutic
target for the treatment of diseases and injuries that result in muscle atrophy. Targeted …

Abstract Background Myostatin (Mstn) is a negative regulator of muscle growth whose
inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in …