Myostatin is a negative regulator of muscle growth. Loss of myostatin has been shown to
cause increase in skeletal muscle size and improve skeletal muscle function and fibrosis in …

Myostatin (Mstn) is a member of the transforming growth factor‐beta family that negatively
regulates skeletal muscle mass. Mstn knockout mice have greater skeletal muscle mass …

Myostatin was identified more than 20 years ago as a negative regulator of muscle mass in
mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of …

Myostatin is a TGF-β family member and a negative regulator of skeletal muscle growth. It
has been proposed that reduction or elimination of myostatin could be a treatment for …

Absence of functional myostatin (MSTN) during fetal development results in adult skeletal
muscle hypertrophy and hyperplasia. To more fully characterize MSTN loss in hindlimb …

Skeletal muscle is the largest organ in the human body, and plays an important role in body
movement and metabolism. Skeletal muscle mass is lost in genetic disorders such as …

The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has
been proposed as a treatment for various muscle-wasting disorders. Here, we have …

Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target
for muscle disease therapy because of its role as a negative regulator of muscle growth and …

Myostatin is a negative regulator of muscle mass. Important advances in our understanding
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …