The purpose of our study was to compare two acquired muscle atrophies and the use of
myostatin inhibition for their treatment. Myostatin naturally inhibits skeletal muscle growth by …

Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, is a critical
autocrine/paracrine inhibitor of skeletal muscle growth. Since the first observed double …

Skeletal muscle fibrosis and impaired muscle regeneration are major contributors to muscle
wasting in Duchenne muscular dystrophy (DMD). Muscle growth is negatively regulated by …

It is unclear whether the muscle hypertrophy induced by loss of myostatin signaling in
mature muscles is maintained only by increased protein synthesis or whether reduced …

Skeletal muscle fibrosis is a defining feature of the muscular dystrophies in which contractile
myofibers are replaced by fibroblasts, adipocytes and extracellular matrix. This maladaptive …

Background Spinal muscular atrophy (SMA) is caused by genetic defects in the survival
motor neuron 1 (SMN1) gene that lead to SMN deficiency. Different SMN‐restoring therapies …

Abstract While Type 1 Diabetes Mellitus (T1DM) is characterized by hypoinsulinemia and
hyperglycemia, persons with T1DM also develop insulin resistance. Recent studies have …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Many growth factors are intimately bound to the extracellular matrix, with regulated
processing and release leading to cellular stimulation. Myostatin and GDF11 are closely …