Insulin resistance (IR) in skeletal muscle is a prerequisite for type 2 diabetes and is often
associated with obesity. IR also develops alongside muscle atrophy in older individuals in …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Human aging is accompanied by a progressive loss of muscle mass (sarcopenia). We tested
the hypothesis that older males (OMs, 70±4 yr, n= 9) would have a blunted myogenic …

Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological
and pathophysiological processes, including normal aging. There are no approved …

Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …

Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle
cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin …

There is no consensus about whether making muscles abnormally large by reducing
myostatin activity affects force-generating capacity or the ability to perform activities requiring …

Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic
target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to …

Transgenic mice lacking a functional myostatin (MSTN) gene demonstrate greater skeletal
muscle mass resulting from muscle fiber hypertrophy and hyperplasia (McPherron, AC, AM …

Myostatin is a negative regulator of skeletal muscle growth and in fact acts as a potent
inducer of “cachectic-like” muscle wasting in mice. The mechanism of action of myostatin in …