Erlotinib for first line treatment in unselected patients (p) with advanced or metastatic non-small cell lung carcinoma (NSCLC)

U Jimenez, A Gurpide, D Isla… - Journal of Clinical …, 2007 - ascopubs.org
7639 Background: Erlotinib is an orally available selective EGFR tyrosine-kinase inhibitor.
Erlotinib is approved for the treatment of patients (p) with advanced or metastatic NSCL that …

Efficacy and safety of erlotinib in the treatment for advanced non-small cell lung cancer in Chinese patients

YL Wu, ML Liao, SK Qin, Y Sun… - Zhonghua Zhong liu za zhi …, 2010 - europepmc.org
Objective To observe the efficacy and the adverse effects of erlotinib in the treatment for
advanced non-small cell lung cancer (NSCLC) in Chinese patients. Methods From …

Erlotinib after Gefitinib failure in female never-smoker Asian patients with pulmonary adenocarcinoma

SH Sim, SW Han, DY Oh, SH Lee, DW Kim, SA Im… - Lung Cancer, 2009 - Elsevier
The activity of erlotinib after gefitinib failure in non-small cell lung cancer patients with all
four favorable clinical factors including female, never smoker, Asian, and adenocarcinoma …

Erlotinib in patients with advanced non-small-cell lung cancer: impact of dose reductions and a novel surrogate marker

D Binder, AC Buckendahl, RH Hübner, P Schlattmann… - Medical Oncology, 2012 - Springer
Erlotinib is a relatively well-tolerated treatment option for patients with advanced non-small-
cell lung cancer (NSCLC). Some patients suffer from severe skin toxicity or diarrhea, making …

Safety of erlotinib treatment in outpatients with previously treated non-small-cell lung cancer in Japan

H Nagai, S Tanaka, M Niimi, N Seo, T Sasaki… - International journal of …, 2011 - Springer
Purpose Erlotinib is the first epidermal growth factor receptor–tyrosine kinase inhibitor
shown to provide a survival benefit for advanced non-small-cell lung cancer (NSCLC) …

The risk of neutropenia and leukopenia in advanced non-small cell lung cancer patients treated with erlotinib: a prisma-compliant systematic review and meta-analysis

JG Zhou, X Tian, L Cheng, Q Zhou, Y Liu, Y Zhang… - Medicine, 2015 - journals.lww.com
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a critical
member of systemic therapy for advanced non-small-cell lung cancer (NSCLC). Erlotinib is …

Erlotinib in the treatment of non-small cell lung cancer: current status and future developments

C Gridelli, P Maione, MA Bareschino… - Anticancer …, 2010 - ar.iiarjournals.org
Erlotinib is an orally small molecule inhibiting the tyrosine kinase activity of the epidermal
growth factor receptor (EGFR). Currently, erlotinib, at a standard oral daily dose of 150 mg, is …

A phase II trial of erlotinib as front-line treatment in clinically selected patients with non–small-cell lung cancer

AG Pallis, A Voutsina, N Kentepozidis, S Giassas… - Clinical Lung Cancer, 2012 - Elsevier
Background The purpose of this study was to evaluate the efficacy of erlotinib as front-line
treatment in clinically selected patients with non–small-cell lung cancer (NSCLC). Patients …

Erlotinib: a new therapeutic approach for non-small cell lung cancer

P Bonomi - Expert opinion on investigational drugs, 2003 - Taylor & Francis
Although treatment with cytotoxic agents has produced modest survival improvement in
patients with stage III and IV non-small cell lung cancer (NSCLC), it appears that a plateau …

Erlotinib in non-small cell lung cancer (NSCLC): Interim safety analysis of the TRUST study

U Gatzemeier, A Ardizzoni, K Horwood… - Journal of Clinical …, 2007 - ascopubs.org
7645 Background: In patients (pts) with relapsed NSCLC, erlotinib 150 mg/d significantly
prolonged survival, delayed symptom progression, and improved quality of life versus …