RNA-binding protein HuR mediates transforming growth factor (TGF)-β1-induced
profibrogenic actions. Up-regulation of Sphingosine kinase 1 (SphK1) is involved in TGF-β1 …

Activation of hepatic stellate cells (HSCs) is an essential event in the initiation and
progression of liver fibrosis. MicroRNAs have been shown to play a pivotal role in regulating …

Background/Aims: HOTTIP is a critical modulator in human diseases including liver cancer,
but its role and molecular biological mechanisms in liver fibrosis are still unclear. Methods …

Background & aims Liver fibrosis characterizes advanced chronic liver disease, and
persistent activation of hepatic stellate cells (HSCs) is the primary cause of excessive …

RNA‐binding proteins (RBPs) play a major role in the control of messenger RNA (mRNA)
turnover and translation rates. We examined the role of the RBP, human antigen R (HuR) …

Yes-associated protein (YAP) is a significant downstream protein in the Hippo signaling
pathway with important functions in cell proliferation, apoptosis, invasion and migration. YAP …

Homeodomain-interacting protein kinase 2 (HIPK2), a member of HIPKs family, is
considered as a key regulator in fibrosis. However, the roles of HIPK2 in hepatic stellate …

Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC)
have been thought to be a potential therapeutic target for liver fibrosis. Previous studies …

Methods The immortalized HSCs, LX-2 and JS-1cells were used for the in vitro study. in
vitro, the adeno-associated viruses adeno-associated virus-sh-S1PR2 and JTE-013 were …

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ)
are key regulators of cell proliferation and organ size; however, their physiological …