The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches

JA Lieberman, D Perkins, A Belger, M Chakos… - Biological …, 2001 - Elsevier
Schizophrenia is commonly considered a neurodevelopmental disorder that is associated
with significant morbidity; however, unlike other neurodevelopmental disorders, the …

Altering the course of schizophrenia: progress and perspectives

MJ Millan, A Andrieux, G Bartzokis… - Nature reviews Drug …, 2016 - nature.com
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Pathophysiologic mechanisms in the pathogenesis and clinical course of schizophrenia

JA Lieberman - Journal of Clinical Psychiatry, 1999 - psychiatrist.com
It is widely accepted that schizophrenia originates from abnormalities occurring during the
early stages of neural development. Although large studies have revealed behavioral …

Late-onset schizophrenia: an overview

MJ Harris, DV Jeste - Schizophrenia Bulletin, 1988 - academic.oup.com
Onset of schizophrenia after the age of 40 has been a controversial topic. We reviewed more
than 30 publications (mainly from Europe) on this subject. Many of the studies had …

Pathophysiology of early onset schizophrenia

M Kyriakopoulos, S Frangou - International Review of Psychiatry, 2007 - Taylor & Francis
Early onset schizophrenia (with onset before adulthood) represents a rarer and possibly
more severe form of the disorder which has received particular attention in the last two …

Onset and early course of schizophrenia

H Häfner, K Maurer, W Löffler, S Bustamante… - Search for the Causes of …, 1995 - Springer
When, with what symptoms and how schizophrenia really begins, and how this beginning
can be distinguished from already existing deficits or antecedents are all interesting …

Schizophrenia: new pathological insights and therapies

LF Jarskog, S Miyamoto, JA Lieberman - Annu. Rev. Med., 2007 - annualreviews.org
The neurodevelopmental hypothesis of schizophrenia posits an interaction between multiple
susceptibility genes and one or more environmental insults in early life, resulting in altered …

Schizophrenia—an overview

RA McCutcheon, TR Marques, OD Howes - JAMA psychiatry, 2020 - jamanetwork.com
Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …

The schizophrenia prodrome revisited: a neurodevelopmental perspective

BA Cornblatt, T Lencz, CW Smith… - Schizophrenia …, 2003 - academic.oup.com
Despite the widespread acceptance of the neurodevelopmental model of schizophrenia, its
application to research concerned with the prodromal phase of illness is limited. Little …

Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation

G Bartzokis - Neuropsychopharmacology, 2002 - Elsevier
Recent evidence suggests that the temporal extent of brain development/maturation can be
expanded into middle age when maximal white matter volume and myelination are reached …