Extended therapy with ipratropium is associated with improved lung function in patients with COPD: a retrospective analysis of data from seven clinical trials

SI Rennard, CW Serby, M Ghafouri, PA Johnson… - Chest, 1996 - Elsevier
Objective Bronchodilators are routinely used in the long-term therapy of patients with COPD.
These drugs are generally evaluated for their short-term bronchodilatory effects. Long-term …

Standard and double dose ipratropium bromide and combined ipratropium bromide and inhaled metaproterenol in COPD

EJ LeDoux, JF Morris, WP Temple, C Duncan - Chest, 1989 - Elsevier
Inhaled ipratropium bromide (IPR) is effective in the management of COPD. The purpose of
this study was to determine if doubling the standard dose of IPR resulted in greater …

Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: response by beta-agonist reversibility

ER Bleecker, A Emmett, G Crater, K Knobil… - Pulmonary pharmacology …, 2008 - Elsevier
This retrospective analysis of data from two multi-center, randomized, double-blind, parallel
group studies compared the efficacy of fluticasone propionate/salmeterol (FSC) 250/50mcg …

In patients with COPD, treatment with a combination of formoterol and ipratropium is more effective than a combination of salbutamol and ipratropium: a 3-week …

AD D'Urzo, MC De Salvo, A Ramirez-Rivera, J Almeida… - Chest, 2001 - Elsevier
Study objectives: To compare the efficacy of adding formoterol or salbutamol to regular
ipratropium bromide treatment in COPD patients whose conditions were suboptimally …

Bronchodilating Effects of Combined Therapy With Clinical Dosages of Ipratropium Bromide and Salbutamol for Stable COPD:: Comparison With Ipratropium Bromide …

A Ikeda, K Nishimura, H Koyama, T Izumi - Chest, 1995 - Elsevier
Several studies have suggested that anticholinergics are at least equal to or may be
superior to beta agonists in the treatment of stable COPD. However, since most previous …

Effects of short-acting bronchodilators added to maintenance tiotropium therapy

HAM Kerstjens, TA Bantje, PB Luursema… - Chest, 2007 - Elsevier
Background Combining bronchodilators has been shown to be beneficial in patients with
COPD. The additive effects of short-acting bronchodilators added to maintenance tiotropium …

Pharmacoeconomic evaluation of a combination of ipratropium plus albuterol compared with ipratropium alone and albuterol alone in COPD

M Friedman, CW Serby, SS Menjoge, JD Wilson… - Chest, 1999 - Elsevier
Study objective To conduct a post hoc pharmacoeconomic evaluation of two double-blind,
randomized, prospective, parallel group studies comparing the long-term efficacy and safety …

Bronchodilator responsiveness in patients with COPD

DP Tashkin, B Celli, M Decramer, D Liu… - European …, 2008 - Eur Respiratory Soc
The degree of acute improvement in spirometric indices after bronchodilator inhalation
varies among chronic obstructive pulmonary disease (COPD) patients, and depends upon …

The role of long-acting bronchodilators in the management of stable COPD

DP Tashkin, CB Cooper - Chest, 2004 - Elsevier
Bronchodilators form the foundation of symptomatic treatment of COPD. Several long-acting
bronchodilators are now available for use in COPD, but publications of large-scale studies of …

A comparison of inhaled ipratropium, oral theophylline plus inhaled β-agonist, and the combination of all three in patients with COPD

JP Karpel, A Kotch, M Zinny, J Pesin, W Alleyne - Chest, 1994 - Elsevier
To evaluate the role of inhaled ipratropium bromide alone vs oral theophylline plus inhaled
β-agonist or the combination of all three in patients with stable COPD, the following double …