Rationale Clozapine levels are advocated in the monitoring of patients on this drug and
have now been used for a number of years. A safety-related threshold has also been …

Abstract Background and Objectives Although therapeutic drug monitoring of clozapine is
recommended, its optimisation is often adjusted only on the basis of dosage. The aim of this …

Therapeutic drug monitoring (TDM) is frequently utilized in the treatment of psychiatric
conditions, but its clinical application concerning the use of clozapine is unclear. We present …

Objectives Clozapine levels may be a more useful predictor of therapeutic response than the
dose, given the variability in clozapine metabolism between individuals. We therefore …

It has been suggested that the minimum effective serum clozapine concentration for an
acceptable clinical response (threshold value) is about 400 μg/L. This article argues against …

Introduction Therapeutic drug monitoring (TDM) of clozapine is a very useful method for
verifying both the correct intake and the interindividual variability of its metabolism, thereby …

Clozapine is associated with non-neurological side effects that can be subjectively
unpleasant and/or clinically serious. We sought to:(i) assess the nature and prevalence of …

Clozapine is an atypical antipsychotic medication with proven efficacy in the management of
refractory schizophrenia. It is also recommended for patients who do not tolerate the …

Clozapine has demonstrated superior efficacy in relieving positive and negative symptoms
intreatment-resistant schizophrenic patients; unlike other antipsychotics, it causes minimal …

Clozapine is the gold standard for treatment-resistant schizophrenia. Serious and even life-
threatening adverse effects, mostly granulocytopenia, myocarditis, and constipation, are of …