Aims Precise evaluation of proliferative activity is essential for the stratified treatment of
luminal‐type breast cancer (BC). Immunohistochemical staining of Ki‐67 has been widely …

Background Ki67 reflects the proliferation activity in breast cancer (BC). However, an optimal
method for its assessment in clinical settings has yet to be robustly defined. In this study we …

Aims Ki67 is a well‐established immunohistochemical marker associated with cell
proliferation that has prognostic and predictive value in breast cancer. Quantitative …

Gudlaugsson E, Skaland I, Janssen EAM, Smaaland R, Shao Z, Malpica A, Voorhorst F &
Baak JPA (2012) Histopathology Comparison of the effect of different techniques for …

Objective Ki67 is a prognostic and predictive marker in breast cancer (BC). However,
manual scoring (MS) by visual assessment suffers from high inter-observer variability which …

Abstract Background Routine analysis of Ki-67 is not widely recommended for clinical
decision-making because of poor reproducibility. Furthermore, counting numerous cells can …

Aims During pathological examination of breast tumours, proliferative activity is routinely
evaluated by a count of mitoses. Adding immunohistochemical stains of Ki67 provides extra …

Aims The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple
potential uses in breast cancer, but an unacceptable level of interlaboratory variability has …

Abstract Ki-67 proliferative index (Ki-67) is a predictive and prognostic factor in breast
cancer (BC). However, some international committees do not recommend its use in routine …

Background The value of KI67 in breast cancer prognostication has been questioned due to
concerns on the analytical validity of visual KI67 assessment and methodological limitations …