Is high dosage testosterone an effective male contraceptive agent?

AM Matsumoto - Fertility and sterility, 1988 - Elsevier
In male contraceptive trials, approximately half of normal men become azoospermic on high
dosages of testosterone enanthate (TE), whereas the other half of men become severely …

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. II. Pharmacokinetics and pharmacodynamics …

RA Anderson, FC Wu - The Journal of Clinical Endocrinology & …, 1996 - academic.oup.com
Hormonal suppression of spermatogenesis is currently being investigated as a method of
reversible male contraception. However, administration of exogenous testosterone (T) …

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. I: Plasma luteinizing hormone, follicle …

EM Wallace, SM Gow, FC Wu - The Journal of Clinical …, 1993 - academic.oup.com
Sex-steroid based male contraceptive regimes induce azoospermia in only 40-70% of
Caucasian men. The reason (s) why the remainder maintains a low level of …

Oligozoospermia induced by exogenous testosterone is associated with normal functioning residual spermatozoa

C Wang, A Leung, L Superlano, B Steiner… - Fertility and sterility, 1997 - Elsevier
Objective: To determine the functional capacity of residual spermatozoa in semen samples
from normal men with T enanthate-induced oligozoospermia. Design: Prospective clinical …

Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male …

JK AMORY, BD ANAWALT, WJ BREMNER… - Journal of …, 2001 - Wiley Online Library
Weekly intramuscular administration of testosterone esters such as testosterone enanthate
(TE) suppresses gonadotropins and spermatogenesis and has been studied as a male …

Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising …

RA Bebb, BD Anawalt, RB Christensen… - The Journal of …, 1996 - academic.oup.com
Studies using high dose testosterone (T) administration in normal men as a male
contraceptive have resulted in azoospermia rates of only 50-70%. Previous studies of T and …

Effect of chronic administration of testosterone enanthate on sperm production and plasma testosterone, follicle-stimulating hormone, and luteinizing hormone levels …

E Steinberger, KD Smith - Fertility and Sterility, 1977 - Elsevier
Sixteen healthy adult male volunteers were studied to determine whether it would be
possible to maintain azoospermia with testosterone enanthate (TE) administered at a dose …

Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men

YL Gui, CH He, JK Amory, WJ Bremner… - Journal of …, 2004 - Wiley Online Library
Monthly injections of testosterone undecanoate (TU) act as a male contraceptive by
reversibly suppressing spermatogenesis to azoospermia or severe oligoazoospermia in …

Hormonal male contraception in men with normal and subnormal semen parameters

E Nieschlag, E Vorona, M Wenk… - … journal of andrology, 2011 - Wiley Online Library
Hormonal male contraception based on testosterone alone or on a combination of
testosterone with a gestagen has been shown to suppress spermatogenesis effectively and …

Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men

D Kinniburgh, H Zhu, L Cheng, AT Kicman… - Human …, 2002 - academic.oup.com
BACKGROUND: Effective hormonal male contraception requires a high prevalence of
spermatogenic suppression, which has proved particularly difficult in Caucasian …