Background. The global emergence of carbapenem-resistant Enterobacteriaceae highlights
the urgent need to reduce carbapenem dependence. The phase 3 RECAPTURE program …

Objectives: The aim of this prospective phase II, randomized, investigator-blinded study
(NCT00690378) was to compare the efficacy and safety of ceftazidime–avibactam and …

Importance Meropenem-vaborbactam is a combination carbapenem/beta-lactamase
inhibitor and a potential treatment for severe drug-resistant gram-negative infections …

Background There is a need for oral antibiotic agents that are effective against multidrug-
resistant gram-negative uropathogens. Tebipenem pivoxil hydrobromide is an orally …

Abstract Background Carbapenem-resistant Enterobacterales species and multidrug-
resistant Pseudomonas aeruginosa are global health threats. Cefepime–taniborbactam is …

Importance Cefepime/enmetazobactam is a novel β-lactam/β-lactamase inhibitor
combination and a potential empirical therapy for resistant gram-negative infections …

The prospective, multicenter, double-blind study presented in this report evaluated whether
or not intravenous (IV) administration of doripenem, a carbapenem with bactericidal activity …

Background Carbapenems are frequently the last line of defence in serious infections due to
multidrug-resistant Gram-negative bacteria, but their use is threatened by the growing …

The global threat of the spread of carbapenem resistance in Enterobacteriaceae has led to
the search for new antibacterials. Intravenous meropenem/vaborbactam (Vabomere™) is …

Background: Doripenem monohydrate, a broad-spectrum carbapenem antibiotic, has been
approved by the US Food and Drug Administration for the treatment of complicated intra …