Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases
cirrhosis and hepatocellular carcinoma. The progression of liver disease is controlled by a …

Interleukins represent a class of immunomodulatory cytokines, small intercellular signaling
proteins, that are critically involved in the regulation of immune responses. They are …

Liver pathologies (fibrosis, cirrhosis, alcoholic, non-alcoholic diseases and hepatocellular
carcinoma) represent one of the most common causes of death worldwide. A number of …

The pyrogenic property being the first activity described, members of the interleukin-1
superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are …

Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …

IL-18 is a pleiotropic cytokine and is produced by various types of cells including activated
macrophages, particularly Kupffer cells. IL-18 has potential to activate inflammatory …

ABSTRACT The interleukin 6 (IL6) family of proteins regulate important cellular processes
and act through a variety of signaling pathways via a shared gp130 receptor. In the liver …

It is well established that interleukin (IL)‐22 has hepatoprotective and antifibrotic functions in
acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis …

Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality
and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is …

Cirrhosis is a common final pathway for most chronic liver diseases; representing an
increasing burden worldwide and is associated with increased morbidity and mortality …