Current DNA methylation assays are limited in the flexibility and efficiency of characterizing
a large number of genomic targets. We report a method to specifically capture an arbitrary …

Studies of epigenetic modifications would benefit from improved methods for high-
throughput methylation profiling. We introduce two complementary approaches that use next …

We report a single-cell bisulfite sequencing (scBS-seq) method that can be used to
accurately measure DNA methylation at up to 48.4% of CpG sites. Embryonic stem cells …

DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based
profiling methods. The four most frequently used sequencing-based technologies are the …

The biological roles of DNA methylation have been elucidated by profiling methods based
on whole-genome or reduced-representation bisulfite sequencing, but these approaches do …

The heterogeneity of DNA methylation within a population of cells necessitates DNA
methylome profiling at single-cell resolution. Recently, we developed a single-cell reduced …

DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …

DNA methylation patterns in the genome both reflect and help to mediate transcriptional
regulatory processes. The digital nature of DNA methylation, present or absent on each …

The faithful transmission of DNA methylation patterns through cell divisions is essential for
the daughter cells to retain a proper cell identity. To achieve a comprehensive assessment …