Alternative splicing is widely recognized for its roles in regulating genes and creating gene
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …

The vast majority of multi-exon genes in higher eukaryotes are alternatively spliced and
changes in alternative splicing (AS) can impact gene function or cause disease. High …

Background Through alternative splicing, most human genes produce multiple isoforms in a
cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing …

Single-cell sequencing technologies have revolutionised the life sciences and biomedical
research. Single-cell sequencing provides high-resolution data on cell heterogeneity …

Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of
proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a …

Alternative gene splicing is a common phenomenon in which a single gene gives rise to
multiple transcript isoforms. The process is strictly guided and involves a multitude of …

RNA alternative splicing, a post-transcriptional stage in eukaryotes, is crucial in cellular
homeostasis and disease processes. Due to the rapid development of the next-generation …

Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

Alternative splicing alterations have been widely related to several human diseases
revealing the importance of their study for the success of translational medicine. Differential …

Alternative splicing is a key cellular mechanism for generating distinct isoforms, whose
relative abundances regulate critical cellular processes. It is therefore essential that …