[PDF][PDF] Rutin Ameliorates Hepatic Fibrosis via Targeting Hepatic Stellate Cells' Activation, Proliferation and Apoptosis

M Safar - 2021 - buescholar.bue.edu.eg
Despite rutin, extracted from black mulberry, has several pharmacological activities, its exact
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study …

Rutin ameliorates hepatic fibrosis via targeting hepatic stellate cells' activation, proliferation and apoptosis

WH El-Maadawy, SH Seif el-Din, SM Ezzat… - Journal of Herbs …, 2021 - Taylor & Francis
Despite rutin, extracted from black mulberry, has several pharmacological activities, its exact
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study …

Tricetin protects against liver fibrosis through promoting autophagy and Nrf2 signaling in hepatic stellate cells

W Li, R Lv, T Zou, M Chen - Life Sciences, 2024 - Elsevier
Aims The study aims to investigate the role and underlying mechanisms of tricetin in
regulating hepatic stellate cells (HSCs) activation. Main methods We treated human hepatic …

Bromelain mitigates liver fibrosis via targeting hepatic stellate cells in vitro and in vivo

AA Sayed, AM Soliman, M Marzouk, FF Mohammed… - Tissue and Cell, 2023 - Elsevier
Various therapeutic approaches are conducted for regression of liver fibrosis and prevent
possible further carcinogenic transformation. This study was aimed to assess the …

[HTML][HTML] Rutin mitigates hepatic fibrogenesis and inflammation through targeting TLR4 and P2X7 receptor signaling pathway in vitro and in vivo

LS Hou, ZY Cui, P Sun, HQ Piao, X Han, J Song… - Journal of Functional …, 2020 - Elsevier
Rutin is a flavonol glycoside widely existing in plants, used as food antioxidant and
nutritional enhancer. Rutin has vitamin P-like effect and anti-inflammatory effect. This study …

[HTML][HTML] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis

NM El-Lakkany, WH El-Maadawy, SHS El-Din… - Asian Pacific journal of …, 2017 - Elsevier
Objective To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods The …

Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways

J Li, X Li, W Xu, S Wang, Z Hu, Q Zhang… - Liver …, 2015 - Wiley Online Library
Abstract Background & Aims Luteolin has been reported to exert antifibrogenic effects in CC
l4‐induced hepatic fibrosis in mice. However, limited information is available on the cellular …

[HTML][HTML] Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway

L Zhou, X Dong, L Wang, L Shan, T Li, W Xu, Y Ding… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Although many advances have been made in understanding the pathogenesis of liver
fibrosis, few options are available for treatment. Casticin, one of the major flavonoids in …

[PDF][PDF] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis

SM Ezzat, MM Safar, S Saleh - Asian Pacific Journal of Tropical …, 2017 - academia.edu
Objective: To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods: The …

Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-β/Smad signaling pathway

X Liu, X Zhao - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. Scoparone, a
major constituent isolated from Artemisia capillaris, was reported to possess …