Cancer stem cells (CSCs) are the subpopulation of cells within a tumor that can self-renew,
differentiate into multiple lineages, and drive tumor growth. Here we describe a two-pronged …

Recent observations indicate that, in several types of human cancer, only a phenotypic
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …

Colon carcinoma is one of the leading causes of death from cancer and is characterized by
a heterogenic pool of cells with distinct differentiation patterns. Recently, it was reported that …

First developed for hematologic disorders, the concept of cancer stem cells (CSCs) was
expanded to solid tumors, including colorectal cancer (CRC). The traditional model of colon …

The biology of the normal colonic mucosa suggests that colon cancer originates from normal
colon stem cells. CD44 cancer stem cells have been identified in breast and prostate cancer …

For the past half century, oncologists have had systemic drugs available, agents that are
able to induce tumor responses in patients with colorectal cancer. However, in cases of …

Background: Despite earlier studies demonstrating in vitro propagation of solid tumour
cancer stem cells (CSCs) as non-adherent tumour spheres, it remains controversial as to …

BACKGROUND & AIMS: Tumor-initiating cells are a subset of tumor cells with the ability to
form new tumors; however, they account for less than 0.001% of the cells in colorectal or …

Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is
responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal …

Colorectal cancer (CRC) is the second leading cause of death from cancer in the United
States. Aggressive research in the last decade has led to a wealth of information about this …