Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

MITF and pigmentation play important roles in both normal melanocyte and transformed
melanoma cell biology. MITF is regulated by many pathways and it also regulates many …

Various environmental and genetic factors affect the development and progression of skin
cancers including melanoma. Melanoma development is initially triggered by environmental …

Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

The protein kinase B-RAF is a human oncogene that is mutated in∼ 70% of human
melanomas and transforms mouse melanocytes. Microphthalmia-associated transcription …

Microphthalmia‐associated transcription factor (MITF) plays a pivotal role in melanocyte
survival and differentiation. Nevertheless, until now it has not been possible to show that …