ADAMTS-4 (aggrecanase1) is believed to play an important role in the degradation of
aggrecan during the progression of joint diseases. ADAMTS-4 is synthesized as a latent pro …

Members of the ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs)
family share common structural features including a disintegrin domain, a zinc …

Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of
articular cartilage. Although disease initiation may be multi‐factorial, the cartilage …

ADAMTS4 (aggrecanase-1), a secreted enzyme belonging to the ADAMTS (adisintegrin and
metalloproteinase with thrombospondin motifs) gene family, is considered to play a key role …

Increasing evidence is accumulating for the importance of the aggrecanases ADAMTS-4
and ADAMTS-5 in cartilage degradation in arthritis. Recent work from a number of …

ADAMTS proteinases, belonging to the adamalysin subfamily of metalloproteinases, have
been implicated in a variety of cellular events such as morphogenesis, cell migration …

Aggrecanases have been characterized as proteinases that cleave the Glu 373-Ala 374
bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging …

Summary Objective ADAMTS5 (aggrecanase-2) has been demonstrated to be crucial in the
development of osteoarthritis (OA), by use of several mouse mutants carrying either …

Objective Recent published studies have shown that cartilage from ADAMTS‐5–knockout
mice, but not ADAMTS‐4–or ADAMTS‐1–knockout mice, is significantly protected from …

Introduction Cleavage of aggrecan between residues Glu373–Ala374, which is believed to
be a key event in aggrecan destruction in arthritic diseases, has been attributed to an …