Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …

Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Background: Sepsis is a deadly immunological disorder and its pathophysiology is still
poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory …

Sepsis is a systemic inflammatory response syndrome in response to severe infection. An
overwhelming systemic response brought about by the release of various inflammatory …

Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …

Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

The sepsis syndrome is thought to occur when microbial products activate Toll-like receptors
stimulating widespread inflammation, in turn causing organ failure, shock and death …