The pathway for base pair opening within a B-DNA duplex is investigated by theoretical
molecular modeling. The results show that the disruption of a single base pair is …

Stretching experiments with long double-stranded DNA molecules in physiological ambient
revealed a force-induced transition at a force of 65pN. During this transition between B-DNA …

Preservation of genetic information in DNA relies on shielding the nucleobases from
damage within the double helix. Thermal fluctuations lead to infrequent events of the Watson …

During the past decade, the issue of strong bending of the double helix has attracted a lot of
attention. Here, we overview the major experimental and theoretical developments in the …

As double-stranded DNA is stretched to its B-form contour length, models of polymer
elasticity can describe the dramatic increase in measured force. When the molecule is …

A theory of the unzipping of double-stranded DNA is presented and is compared to recent
micromanipulation experiments. It is shown that the interactions that stabilize the double …

The highly cooperative elongation of a single B-DNA molecule to almost twice its contour
length upon application of a stretching force is interpreted as force-induced DNA melting …

Molecular dynamics simulations were used to model the response of several double-
stranded dodecamers to gradually increasing tension applied to the opposing 3 'ends of the …

When a long DNA molecule is stretched beyond its B-form contour length, a transition occurs
in which its length increases by a factor of 1.7, with very little force increase. A quantitative …

The dynamic behaviour of DNA is of fundamental importance to many cellular processes.
One principal characteristic, central to transcription and replication, is the ability of the …