Cryptococcal infections are primarily caused by two related fungal species: Cryptococcus
neoformans and Cryptococcus gattii. It is well known that C. neoformans generally affects …

Vaccine-induced immune responses, including neutrophil, macrophage, and T-cell
responses, ameliorate cryptococcosis caused by Cryptococcus gattii. However, whether …

Cryptococcus neoformans is an opportunistic fungal pathogen that may lead to life-
threatening meningoencephalitis and pulmonary infections in immunosuppressed hosts …

The importance of T cell-mediated immunity for resistance to the disease (cryptococcal
disease) caused by Cryptococcus neoformans is incontrovertible, but whether Ab immunity …

Cell-mediated immunity plays an important role in immunity to the pathogenic fungus
Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C …

Cell-mediated immunity is critical to host defenses against the fungal infection
cryptococcosis. Here, two functions critical to effective cell-mediated immunity (CMI) …

The ability of Cryptococcus neoformans to cause disease in humans varies significantly
among strains with highly related genotypes. In general, environmental isolates of …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

Maintenance of immunity to persistent pathogens is poorly understood. In this study, we
used a murine model of persistent pulmonary fungal infection to study the ongoing cell …

Background Cryptococcus neoformans causes serious disease in immunocompromised
individuals, leading to over 600,000 deaths per year worldwide. Part of this impact is due to …