ELANIN PIGMENTATION has aroused the curiosity and attention of man since the beginning
of recorded history. This interest stems in part from the social, protective and cosmetic …

5-S-Glutathionyldopa is oxidized at incubation with tyrosinase and dopa producing a black
pigment. The reaction proceeds with the formation of two chromophores with absorption …

The occurrence of high amounts of dopa has been demonstrated chemically in the piliary
system of pigmented animals (guinea‐pig, rabbit, and dog). Histochemically, a …

The melanogenic activities in the eye of the adult gerbil (Meriones unguiculatus) have been
investigated and compared to those found in the B16 mouse melanoma model. Eye extracts …

How tyrosinase becomes associated with the premelanosomes was investigated by
histochemical demonstration of tyrosinase activity by the use of dihydroxyphenylalanine …

The urine of an albino woman contained small quantities of 5-S-cysteinyldopa; 6-hydroxy-5-
methoxyindole-2-carboxylic acid, a melanin precursor metabolite, was lacking. The 5-S …

The gradual loss of melanin pigment (dedifferentiation) has been demonstrated in
monolayer cultures of proliferating retinal pigment cells of the chick embryo. Pigment was …

Melanin pigments are classified as being either eumelanin or pheomelanin. Eumelanin
consists of indole units derived from 3, 4-dihydroxyphenylalanin (dopa). Pheomelanin …

The autoxidation of dopa to melanin in culture media causes toxicity to retinal pigment
epithelial (RPE) cells and endothelial cells. The damage is specific to cell type and to the …