There is now much evidence suggesting that there are multiple control points in the process
of melanin production. The most fundamental process of melanogenesis is centered on the …

Pigmented tissues from bovine eye were used as a source for isolation of tyrosinase from
normal melanocytes. Tyrosinase is highly hydrophobic and the isolation procedure is mainly …

Tyrosinase [EC 1.14. 18.11, the enzyme critical to the formation of melanin, occurs in vivo as
a number of isozymic forms. These isozymic forms have generally been considered to arise …

Purified soluble tyrosinase isolated from the melanosomes of Harding-Passey mouse
melanoma was incubated with L-dopa. The reaction velocity of the tyrosinase thus incubated …

The regulation of the final steps of the melanogenesis pathway, after L‐2‐carboxy‐2, 3‐
dihydroindole‐5, 6‐quinone (dopachrome) formation, is studied. It is shown that both …

Previous reports have shown that the tyrosinase activities of melanosomes and soluble
tyrosinase isolated from melanoma were diminished when these preparations were …

[2-14 C] Thiouracil and [35 S] thiouracil are incorporated into the melanin of chick retinal
pigment epithelium incubated in vitro. This synthesis of a thiouracil pheomelanin (thiol …

The activity of tyrosinase, the rate-limiting enzyme for melanin synthesis, is higher in Black
skin melanocytes than in melanocytes derived from Caucasian skin. This variation in …

Biosynthesis of pigment melanin in pigment cells (melanocytes, nevus cells, melanoma
cells) constitutes a distinctive but integrated part of intracellular metabolism. Although the …