The complexation of the practically insoluble drug furosemide (acidic pKa 3.22) with lower
generation PAMAM dendrimers showed a significant release dependence on the ionization …

Drug solubility could affect the therapeutic use of a drug because the biological activity of a
drug is only possible if some fraction of a dissolved drug can permeate and overcome …

Approximately 40% of newly developed drugs are rejected by the pharmaceutical industry
and will never benefit a patient because of low water solubility. Another 17% of launched …

Dendrimers are 3D, hyperbranched, tree-like polymers having immense potential in drug
delivery, targeting, diagnosis and as carriers for DNA/gene delivery. Dendrimers have …

Adequate aqueous solubility has been one of the desired properties while selecting drug
molecules and other bio-actives for product development. Often solubility of a drug …

Dendrimers today are known for their three dimensional, monodispersed, highly branched,
macromolecular nano-scopic architecture with number of reactive end groups. Dendrimers …

Drug release from polymer–drug conjugates plays a crucial role on the efficacy. This is
especially true for dendrimers where there is a steric crowding at the surface. The drug …

The polarity and accessibility to the interior of several dendrimers using phenanthrene,
anthracene and tetrabenzonaphtalene as probe molecules have been investigated. In …

A drug is effective in their molecular form; thus solubility in the biological fluid is important.
Pharmaceutical researchers are continuously working on the improvement of solubility of …

Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug
delivery and formulation development. Apart from conventional methods of solubility …