In children, the therapeutic benefits and potential risks associated with drug treatment may
be different from those in adults and will depend on the exposure, receptor sensitivity and …

Key factors undergoing maturational changes accounting for differences in drug metabolism
and disposition in the pediatric population compared with adults are reviewed. Gastric and …

This review focuses on one of the key factors accounting for differences in drug/metabolite
exposure in paediatric and elderly subjects compared with that of the adult population, that …

Pharmacokinetics (PK) of xenobiotics can differ widely between children and adults due to
physiological differences and the immaturity of enzyme systems and clearance mechanisms …

Many physiologic differences between children and adults may result in age-related
changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and …

Age‐dependent developmental changes in toxicokinetics occur in both rats and humans,
particularly in relation to renal function and hepatic xenobiotic metabolism. These processes …

A significant increase in the knowledge base in paediatric clinical pharmacology has
occurred over the past 2 decades and has largely been the result of important scientific and …

Introduction: A large proportion of prescribed drugs to children are administered orally. Age-
related change in factors affecting oral absorption can have consequences for drug dosing …

Most of the pharmacokinetic studies conducted to calculate pediatric drug doses are based
on scaling from adult data using various allometric parameters related to body size …

Recent concern over toxic effects of drugs in newborns, infants and children have stressed
the need for better knowledge of drug kinetics during development. The present review …