Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility

C Wright, S Milne, H Leeson - Reproductive biomedicine online, 2014 - Elsevier
DNA fragmentation is an important factor in the aetiology of male infertility. However, it is still
underevaluated and its inclusion in routine semen analysis is debated. DNA fragmentation …

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

SEM Lewis, RJ Aitken, SJ Conner, G De Iuliis… - Reproductive …, 2013 - Elsevier
Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of
assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo …

[HTML][HTML] Oxidation of sperm DNA and male infertility

L Rashki Ghaleno, AR Alizadeh, JR Drevet… - Antioxidants, 2021 - mdpi.com
One important reason for male infertility is oxidative stress and its destructive effects on
sperm structures and functions. The particular composition of the sperm membrane, rich in …

[HTML][HTML] Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis

M Cocuzza, SC Sikka, KS Athayde… - International braz j urol, 2007 - SciELO Brasil
Oxidative stress (OS) in the reproductive tract is now a real entity and concern due to the
potential harmful effects of high levels of reactive oxygen species (ROS) on sperm number …

Improvement in sperm DNA quality using an oral antioxidant therapy

O Tunc, J Thompson, K Tremellen - Reproductive biomedicine online, 2009 - Elsevier
Oxidative stress is now recognized as a common pathology that affects up to half of all
infertile men. One of the principal mechanisms by which oxidative stress produces infertility …

Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility

M Appasamy, S Muttukrishna, AR Pizzey… - Reproductive …, 2007 - Elsevier
This study investigated the relationship between male reproductive hormones and sperm
DNA damage and markers of oxidative stress in men undergoing infertility evaluation for …

[HTML][HTML] Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility

RA Saleh, A Agarwal, EA Nada, MH El-Tonsy… - Fertility and sterility, 2003 - Elsevier
OBJECTIVE: To examine the effects of increased sperm DNA damage in relation to seminal
oxidative stress in men with idiopathic and male factor infertility. DESIGN: Prospective study …

The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy

P Gharagozloo, RJ Aitken - Human reproduction, 2011 - academic.oup.com
Oxidative stress in the male germ line is thought to affect male fertility and impact upon
normal embryonic development. Accordingly, fertility specialists are actively exploring the …

[HTML][HTML] A comparison between two assays for measuring seminal oxidative stress and their relationship with sperm DNA fragmentation and semen parameters

ST Homa, AM Vassiliou, J Stone, AP Killeen… - Genes, 2019 - mdpi.com
Oxidative stress (OS) is a significant cause of DNA fragmentation and is associated with
poor embryo development and recurrent miscarriage. The aim of this study was to compare …

Oxidative stress and male infertility

S Bisht, M Faiq, M Tolahunase, R Dada - Nature Reviews Urology, 2017 - nature.com
DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …