The measurement and prediction of solubilities of active pharmaceutical ingredients are
crucial in the development of polymorphism and the crystallization process. In this work, the …

In vitro dissolution that predicts the in vivo performance of solid preparations is extremely
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …

Due to different polymorphs demonstrate significant variations in the drug properties such as
solubility, stability and dissolution rate. In this work, we study the shape of the solubility …

The choice of solvent is crucial in the drug crystallization process, and the mechanism of
solvent effect on the crystallization results can be conducive to the selection of solvents. In …

Aripiprazole (ARI) is a third-generation antipsychotic with few side effects but a poor
solubility. Salt formation, as one common form of multicomponent crystals, is an effective …

Aripiprazole (APZ), an effective second-generation antipsychotic drug indicated for the
treatment of schizophrenia, was chosen to investigate its solubility in three binary solvent …

Propose The propose is to investigate the reasons for the insolubility of Form III in water and
to explore the mechanism of the hydration process of Form III. Methods The conformational …

We aimed to evaluate the effect of crystalline forms of aripiprazole, an antipsychotic drug for
schizophrenia, on the dissolution rates and oral pharmacokinetics. Solubility, intrinsic …

The solvent effect significantly influences the morphology of a substance crystallized from
the solution. It is crucial to select appropriate solvent systems to produce active …

Cocrystallization is an important route to tuning the solubility in drugs development,
including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol …