The Effect of Intermolecular Interactions on the Dissolution Property of Aripiprazole
The measurement and prediction of solubilities of active pharmaceutical ingredients are
crucial in the development of polymorphism and the crystallization process. In this work, the …
crucial in the development of polymorphism and the crystallization process. In this work, the …
Establishment of In Vitro Dissolution Based on Similarity with In Vivo Dissolution: A Case Study on Aripiprazole
In vitro dissolution that predicts the in vivo performance of solid preparations is extremely
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …
important in formulation optimization. Fraction absorbed (F a) has been used to screen in …
Cosolvent effect on solubility of aripiprazole in mixed solvents and apparent thermodynamic analysis of dissolution process
Y Wu, L Cheng, J Wu, M Zhai, L Cai - The Journal of Chemical …, 2019 - Elsevier
Due to different polymorphs demonstrate significant variations in the drug properties such as
solubility, stability and dissolution rate. In this work, we study the shape of the solubility …
solubility, stability and dissolution rate. In this work, we study the shape of the solubility …
Mechanistic Study on the Effect of Solvents on Polymorphic Transformation of Aripiprazole by Solvent Property Parameters and Molecular Dynamics Simulation
Z Zheng, X Huang, N Wang, T Wang… - Crystal Growth & …, 2024 - ACS Publications
The choice of solvent is crucial in the drug crystallization process, and the mechanism of
solvent effect on the crystallization results can be conducive to the selection of solvents. In …
solvent effect on the crystallization results can be conducive to the selection of solvents. In …
[HTML][HTML] Improving the solubility of aripiprazole by multicomponent crystallization
Q Zhou, Z Tan, D Yang, J Tu, Y Wang, Y Zhang, Y Liu… - Crystals, 2021 - mdpi.com
Aripiprazole (ARI) is a third-generation antipsychotic with few side effects but a poor
solubility. Salt formation, as one common form of multicomponent crystals, is an effective …
solubility. Salt formation, as one common form of multicomponent crystals, is an effective …
Thermodynamic analysis and molecular dynamic simulation of solid–liquid equilibrium behavior of antipsychotic drug aripiprazole (Form III) in three binary solvent …
H Wang, X Zhang - Journal of Molecular Liquids, 2023 - Elsevier
Aripiprazole (APZ), an effective second-generation antipsychotic drug indicated for the
treatment of schizophrenia, was chosen to investigate its solubility in three binary solvent …
treatment of schizophrenia, was chosen to investigate its solubility in three binary solvent …
Hydration Mechanism and Its Effect on the Solubility of Aripiprazole
Z Zheng, X Huang, N Wang, T Wang, L Zhou… - Pharmaceutical …, 2024 - Springer
Propose The propose is to investigate the reasons for the insolubility of Form III in water and
to explore the mechanism of the hydration process of Form III. Methods The conformational …
to explore the mechanism of the hydration process of Form III. Methods The conformational …
Solution-mediated phase transformation of aripiprazole: Negating the effect of crystalline forms on dissolution and oral pharmacokinetics
S Chung, J Kim, E Ban, J Yun, B Park, A Kim - Journal of Pharmaceutical …, 2020 - Elsevier
We aimed to evaluate the effect of crystalline forms of aripiprazole, an antipsychotic drug for
schizophrenia, on the dissolution rates and oral pharmacokinetics. Solubility, intrinsic …
schizophrenia, on the dissolution rates and oral pharmacokinetics. Solubility, intrinsic …
Exploring the solvent effect on risperidone (form I) crystal morphology: A combination of molecular dynamics simulation and experimental study
Z Cao, Y Wu, M Niu, Y Li, T Li, B Ren - Journal of Molecular Liquids, 2023 - Elsevier
The solvent effect significantly influences the morphology of a substance crystallized from
the solution. It is crucial to select appropriate solvent systems to produce active …
the solution. It is crucial to select appropriate solvent systems to produce active …
[HTML][HTML] New cocrystals of antipsychotic drug aripiprazole: decreasing the dissolution through cocrystallization
W Liu, R Ma, F Liang, C Duan, G Zhang, Y Chen… - Molecules, 2021 - mdpi.com
Cocrystallization is an important route to tuning the solubility in drugs development,
including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol …
including improving and reducing. Five cocrystals of aripiprazole (ARI) with resveratrol …
相关搜索
- dissolution property intermolecular interactions
- effect on solubility dissolution process
- mixed solvents dissolution process
- solubility of aripiprazole multicomponent crystallization
- solubility of aripiprazole hydration mechanism
- dynamics simulation solvent effect
- dynamics simulation crystal morphology
- effect of solvents property parameters
- thermodynamic analysis drug aripiprazole
- equilibrium behavior drug aripiprazole
- solubility of aripiprazole mixed solvents
- effect on solubility mixed solvents