Background: Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of
0.5–1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating …

Attempts to discover genes that are involved in the pathogenesis of major psychiatric
disorders have been frustrating and often fruitless. Concern is building about the need to …

Objectives Aberrant DNA methylation and gene expression have been reported in
postmortem brain tissues of psychotic patients, but until now there has been no systematic …

Recent studies suggest that genetic and environmental factors do not account for all the
schizophrenia risk, and epigenetics also has a role in disease susceptibility. DNA …

Epigenetics plays a crucial role in schizophrenia susceptibility. In a previous study, we
identified over 4500 differentially methylated sites in prefrontal cortex (PFC) samples from …

DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …

Schizophrenia (SCZ) is a complex psychiatric disease with a lifetime morbidity rate of 0.5–
1.0%. To date, aberrant DNA methylation in SCZ has been reported in several studies …

DNA methylation, which is the transference of a methyl group to the 5′-carbon position of
the cytosine in a CpG dinucleotide, is one of the major mechanisms of epigenetic …

Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry
concerns the extent to which epigenetic signatures measured in more accessible tissues …

Importance DNA methylation may play an important role in schizophrenia (SZ), either
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …