Specification of primordial germ cells (PGCs) activates epigenetic reprogramming for
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …

Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …

Epigenetic reprogramming in early germ cells is critical toward the establishment of
totipotency, but investigations of the germline events are intractable. An objective cell culture …

Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …

Germ cells possess the extraordinary and unique capacity to give rise to a new organism
and create an enduring link between all generations. To acquire this property, primordial …

Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are
derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …