Myostatin has been extensively documented as a negative regulator of muscle growth.
Myostatin inhibition is therefore considered an attractive strategy for the treatment of muscle …

Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

GDF-8, also known as myostatin, is a member of the transforming growth factor-β (TGF-β)
superfamily of secreted growth and differentiation factors that is expressed in vertebrate …

By using a conditional gene targeting approach exploiting the cre‐lox system, we show that
postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

Myostatin, a TGF-β family member, is an important regulator of adult muscle size. While
extensively studied in vitro, the mechanisms by which this molecule mediates its effect in …

Either increased protein synthesis or prolonged protein half-life is necessary to support the
excessive muscle growth and maintenance of enlarged muscles in myostatin-deficient mice …

Myostatin (MSTN), a transforming growth factor (TGF)-β superfamily member, has been
shown to negatively regulate muscle growth by inhibiting muscle precursor cell proliferation …

Glucocorticoids mediate muscle atrophy in many catabolic states. Myostatin expression, a
negative regulator of muscle growth, is increased by glucocorticoids and myostatin …

Mice, and cattle with mutations in the myostatin (GDF8) gene show a marked increase in
body weight and muscle mass, indicating that this new member of the TGF-β superfamily is a …