Nonconsensus West Nile Virus Genomes Arising during Mosquito Infection Suppress Pathogenesis and Modulate Virus Fitness In Vivo

GD Ebel, KA Fitzpatrick, PY Lim, CJ Bennett… - Journal of …, 2011 - Am Soc Microbiol
West Nile virus (WNV) is similar to other RNA viruses in that it forms genetically complex
populations within hosts. The virus is maintained in nature in mosquitoes and birds, with …

[HTML][HTML] Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes

KA Fitzpatrick, ER Deardorff, K Pesko, DE Brackney… - Virology, 2010 - Elsevier
West Nile virus is similar to most other RNA viruses in that it exists in nature as a genetically
diverse population. However, the role of this genetic diversity within natural transmission …

RNAi targeting of West Nile virus in mosquito midguts promotes virus diversification

DE Brackney, JE Beane, GD Ebel - PLoS pathogens, 2009 - journals.plos.org
West Nile virus (WNV) exists in nature as a genetically diverse population of competing
genomes. This high genetic diversity and concomitant adaptive plasticity has facilitated the …

West Nile Virus Experimental Evolution in vivo and the Trade-off Hypothesis

ER Deardorff, KA Fitzpatrick, GVS Jerzak, PY Shi… - PLoS …, 2011 - journals.plos.org
In nature, arthropod-borne viruses (arboviruses) perpetuate through alternating replication
in vertebrate and invertebrate hosts. The trade-off hypothesis proposes that these viruses …

[HTML][HTML] The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice

GVS Jerzak, K Bernard, LD Kramer, PY Shi, GD Ebel - Virology, 2007 - Elsevier
To define the impact of mosquitoes and birds on intrahost WNV population dynamics, the
mutant spectra that arose as a result of 20 serial in vivo passages in Culex pipiens and …

Genetic variation in West Nile virus from naturally infected mosquitoes and birds suggests quasispecies structure and strong purifying selection

G Jerzak, KA Bernard, LD Kramer… - Journal of General …, 2005 - microbiologyresearch.org
Intrahost genetic diversity was analysed in naturally infected mosquitoes and birds to
determine whether West Nile virus (WNV) exists in nature as a quasispecies and to quantify …

Role of the mutant spectrum in adaptation and replication of West Nile virus

AT Ciota, KA Ngo, AO Lovelace… - Journal of General …, 2007 - microbiologyresearch.org
West Nile virus (WNV) has successfully spread throughout the USA, Canada, Mexico, the
Caribbean and parts of Central and South America since its 1999 introduction into North …

[HTML][HTML] Genetic diversity and purifying selection in West Nile virus populations are maintained during host switching

GVS Jerzak, I Brown, PY Shi, LD Kramer, GD Ebel - Virology, 2008 - Elsevier
To investigate differential evolutionary rates and selective forces of WNV in hosts and
vectors, we measured the genetic diversity that arose during alternating passage in …

Virus and host determinants of West Nile virus pathogenesis

MS Diamond - PloS pathogens, 2009 - journals.plos.org
West Nile virus (WNV) is a small, enveloped, mosquitotransmitted, positive-stranded RNA
virus of the Flaviviridae family. This virus is related to other arthropod-borne viruses that …

West Nile Virus fidelity modulates the capacity for host cycling and adaptation

HS Caldwell, K Ngo, JD Pata… - Journal of General …, 2020 - microbiologyresearch.org
The fidelity of flaviviruses is thought to be tightly regulated for optimal fitness within and
between hosts. West Nile virus (WNV) high-fidelity (HiFi) mutations V793I and G806R within …