Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion
F Decloitre, C Lafarge-Frayssinet, M Barroso… - Tumor Biology, 1990 - karger.com
The phenotypic response of rat liver to a carcinogenic protocol involving initiation/selection
and promotion with and without phenobarbital (PB) feeding was studied in pubertal and …
and promotion with and without phenobarbital (PB) feeding was studied in pubertal and …
Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy …
GL Wolff, JEA Leakey, JJ Bazare, JR Harmon… - …, 1991 - academic.oup.com
Higher body and carcass (body-liver) weights in sodium phenobarbital (PB) treated mice
correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a …
correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a …
Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term …
A Hagiwara, T Matsuda, S Tamano, M Kitano, S Imaoka… - Cancer letters, 1996 - Elsevier
The dose-response relationship between liver tumor promoting activity and cytochrome P-
450 (CYP) induction by phenobarbital sodium (PB) was investigated using the liver medium …
450 (CYP) induction by phenobarbital sodium (PB) was investigated using the liver medium …
Facilitated expression of adaptive responses to phenobarbital in putative pre-stages of liver cancer
R Schulte-Hermann, I Timmermann-Trosiener… - …, 1986 - academic.oup.com
Female rats received N-nitrosomorpholine to produce altered cell foci (potential cancer pre-
stages) in the liver, followed by phenobarbital (PB) for 2 weeks. As indicators of adaptive …
stages) in the liver, followed by phenobarbital (PB) for 2 weeks. As indicators of adaptive …
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis
Y Xu, R Maronpot, HC Pitot - Carcinogenesis, 1990 - academic.oup.com
The effects of varying the interval of time between initiation with diethylnitrosamine (DEN)
and promotion by phenobarbital (PB) on the development of altered hepatic foci (AHD) and …
and promotion by phenobarbital (PB) on the development of altered hepatic foci (AHD) and …
Effect of phenobarbital on the altered biochemical phenotypes expressed by hyperplastic liver nodules during hepatocarcinogenesis in the rat
AE Sirica, JK Jicinsky, EJ Vinje, HP Cihla - Advances in Enzyme …, 1984 - Elsevier
The effects of a chronic 8-to 12-week administration of the hepatic tumor promoter,
phenobarbital, on further altering the biochemical enzyme deviation patterns shown by …
phenobarbital, on further altering the biochemical enzyme deviation patterns shown by …
Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay
M Shibutani, N Takahashi, T Kobayashi… - …, 2002 - academic.oup.com
In search of genes that are steadily up-regulated during the promotion stage in
carcinogenesis, suppression PCR subtractive hybridization and following northern blot …
carcinogenesis, suppression PCR subtractive hybridization and following northern blot …
Promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis
T Kitagawa - Toxicologic Pathology, 1986 - journals.sagepub.com
The possible discrepancy between the dose level required for promoting action (when given
after the initiation process, and that needed to exert an anticarcinogenic effect when given …
after the initiation process, and that needed to exert an anticarcinogenic effect when given …
Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 …
ZY Chen, F Farin, CJ Omiecinski, DL Eaton - Carcinogenesis, 1992 - academic.oup.com
This study was conducted to examine relationships between phenobarbital (PB) treatment,
specific cytochrome P450 gene expression patterns and growth rates of hepatic hyperplastic …
specific cytochrome P450 gene expression patterns and growth rates of hepatic hyperplastic …
Two-stage liver carcinogenesis in the mouse
GD Porta, TA Dragani, G Manenti - Toxicologic Pathology, 1987 - journals.sagepub.com
A two-stage protocol for studying liver carcinogenesis was applied to the mouse. The
protocol includes the treatment of 7-day-old mice with a single low dose of an initiating agent …
protocol includes the treatment of 7-day-old mice with a single low dose of an initiating agent …