The aim of this study was to determine for the first time in humans, the efficacy of adding a
low dose oestradiol to a suboptimally suppressive testosterone dose in a depot hormonal …

The gonadotropic hormones, LH and FSH, are required for normal sperm production.
Inhibition of gonadotropin secretion by exogenously administered sex steroids represents …

Studies using high dose testosterone (T) administration in normal men as a male
contraceptive have resulted in azoospermia rates of only 50-70%. Previous studies of T and …

BACKGROUND: Combined testosterone and progestogen preparations are a promising
approach to male hormonal contraception. We investigated the effect of sc etonogestrel with …

Hormones inhibit fertility in men by suppressing sperm production. Testosterone-enanthate
induced azoospermia has proven to provide optimal contraceptive protection. Preliminary …

In male contraceptive trials, approximately half of normal men become azoospermic on high
dosages of testosterone enanthate (TE), whereas the other half of men become severely …

Sex-steroid based male contraceptive regimes induce azoospermia in only 40-70% of
Caucasian men. The reason (s) why the remainder maintains a low level of …

The coadministration of a progestogen with testosterone increases the degree of
suppression of spermatogenesis and is one approach to the development of hormonal male …

Context: Male hormonal contraceptive methods require effective suppression of sperm
output. Objective: The objective of the study was to define the covariables that influence the …

Sperm production starts from puberty in the seminiferous tubules providing testosterone
production by the Leydig cells that takes place in the interstice of the testicles. Normal …