There is much interest in developing anti-myostatin agents to reverse or prevent muscle
atrophy in adults, so it is important to characterize the effects of reducing myostatin activity …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin is a negative regulator of muscle growth and fiber size. Changes in myostatin
expression might contribute to changes in muscle mass associated with various conditions …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin is a paracrine/autocrine factor that inhibits muscle growth, and mutations that
affect myostatin activity or expression produce dramatic increases in muscle mass in several …

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth.
However, myostatin has been also involved in several forms of muscle wasting in adulthood …

Background Skeletal muscle growth and maintenance are essential for human health. One
of the muscle regulatory genes, namely myostatin, a member of transforming growth factor-β …

Increasing the size and strength of muscles represents a promising therapeutic strategy for
musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Key points Myostatin is an important regulator of muscle mass and a potential therapeutic
target for the treatment of diseases and injuries that result in muscle atrophy. Targeted …