Clearance of the hepatitis B virus (HBV), a noncytopathic double-stranded DNA virus,
requires the coordinated response of innate and adaptive, humoral and cellular immune …

Resolution of hepatitis B virus (HBV) infection was believed to be attributed to the cytotoxic T
cell–mediated killing of infected hepatocytes. However, studies in HBV transgenic mice and …

To understand the role of cytotoxic T cells in liver damage and viral control, we used human
histocompatibility leukocyte antigen (HLA)-peptide tetramers that allow direct ex vivo …

During acute type B hepatitis, the proportion of inducer to cytotoxic/suppressor T‐cells is
decreased due to an increase in the concentration of suppressor cells. Similar changes are …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …

Peripheral blood T lymphocytes and T-cell subsets were analyzed in 19 patients with HBV-
associated chronic liver disease, in 9 “autoimmune” chronic active hepatitis patients, and in …

The aim of this study was to elucidate the molecular basis for viral clearance and liver
disease in the pathogenesis of hepatitis B virus (HBV) infection. Using transgenic mice that …

Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated
with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly …

Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

The adaptive immune response is thought to be responsible for viral clearance and disease
pathogenesis during hepatitis B virus infection. It is generally acknowledged that the …