Hepatitis B virus (HBV) infection is a major public health problem worldwide. HBV is not
directly cytotoxic to infected hepatocytes; the clinical outcome of infection results from …

Clinical manifestations of hepatitis B virus (HBV) infection are a balance between viral and
host factors. The immune response against any virus consists of a coordinated defence of …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are global health
problems affecting 600 million people worldwide. Indeed, HBV and HCV are hepatotropic …

It is widely believed that viral clearance is mediated principally by the destruction of infected
cells by CTLs. In this report, we use a transgenic mouse model of HBV replication to …

Considerable evidence suggests that immune mechanisms are involved in the
pathogenesis of both hepatitis B and C. Both CD4+ and CD8+ T cell responses to viral …

ABSTRACT CD8+ T cells are the key cellular effectors mediating the clearance of hepatitis B
virus (HBV) infections. However, early immunological events surrounding the priming of …

During hepatitis B virus (HBV) infection, distinct host-virus interactions may establish the
patterns of viral clearance and persistence and the extent of virus-associated pathology. It is …

Since the hepatitis B virus is noncytopathic, it is generally believed that the individual
specific immune response determines the course of infection. The lack of data about …

An in vitro model was developed that allowed the analysis of hepatitis B virus-specific
cytotoxic T lymphocyte responses in patients suffering from acute and chronic hepatitis B …

The cytokine pattern secreted by T cells on viral antigen recognition is believed to exert a
profound influence on both the type of disease caused by the infecting agent and the final …