Definition of hepatitis B virus (HBV)-specific target antigens recognized by cytotoxic T cells in acute HBV infection.

MU Mondelli, F Bortolotti, P Pontisso… - Clinical and …, 1987 - ncbi.nlm.nih.gov
We have investigated the specificity of cell-mediated cytotoxicity for autologous liver cells in
10 patients with acute hepatitis B in relation to the expression of hepatitis B virus (HBV) …

Innate immune responses in hepatitis B virus (HBV) infection

A Busca, A Kumar - Virology journal, 2014 - Springer
Hepatitis B virus (HBV) infection has a low rate of chronicity compared to HCV infection, but
chronic liver inflammation can evolve to life threatening complications. Experimental data …

Immunobiology and pathogenesis of viral hepatitis

LG Guidotti, FV Chisari - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Study of liver‐targeted regulatory T cells in hepatitis B and C virus in chronically infected patients

H Miyaaki, H Zhou, T Ichikawa, K Nakao… - Liver …, 2009 - Wiley Online Library
Abstract Introduction: Regulatory T cells (Tregs) play a critical role in chronic viral infections.
The role of Tregs in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) is unknown …

Selective expansion of cytotoxic T lymphocytes with a CD4+ CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients …

V Barnaba, A Franco, M Paroli… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
Highly purified CD4+ T cells isolated from liver biopsies of patients with hepatitis B virus-
induced CAH had a strong cytotoxic activity and were comprised of a substantial number of …

The immune response during hepatitis B virus infection

A Bertoletti, AJ Gehring - Journal of General Virology, 2006 - microbiologyresearch.org
Hepatitis B virus (HBV) is a major cause of chronic liver inflammation worldwide. Recent
knowledge of the virological and immunological events secondary to HBV infection has …

Long-lasting memory T cell responses following self-limited acute hepatitis B.

A Penna, M Artini, A Cavalli, M Levrero… - The Journal of …, 1996 - Am Soc Clin Investig
The molecular and cellular basis of long-term T cell memory against viral antigens is still
largely undefined. To characterize anti-viral protection by memory T cells against non …

HBV and the immune response

C Ferrari - Liver international, 2015 - Wiley Online Library
Hepatitis B virus (HBV) infection acquired in adult life is generally self‐limited while chronic
persistence of the virus is the prevalent outcome when infection is acquired perinatally. Both …

Clonal analysis of human T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis

SC Meuer, U Moebius, MM Manns… - European journal of …, 1988 - Wiley Online Library
Human T lymphocytes infiltrating the liver in chronic active hepatitis B (CAH‐B) and primary
biliary cirrhosis were isolated from liver biopsy cores, cloned by limiting dilution technique …

T-lymphocyte cytotoxicity to HBsAg-coated target cells in hepatitis B virus infection

A Alberti, G Realdi, F Bortolotti, AM Rigoli - Gut, 1977 - gut.bmj.com
The cytotoxic effect of peripheral lymphocytes on chicken red blood cells (ChRBC) coated
with purified hepatitis B surface antigen (HBsAg) has been studied as an in vitro parameter …