The mechanisms by which excessive glucocorticoids cause muscular atrophy remain
unclear. We previously demonstrated that dexamethasone increases the expression of …

Glucocorticoids mediate muscle atrophy in many catabolic states. Myostatin expression, a
negative regulator of muscle growth, is increased by glucocorticoids and myostatin …

We cloned and characterized a 3.3-kb fragment containing the 5′-regulatory region of the
human myostatin gene. The promoter sequence contains putative muscle growth response …

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth.
However, myostatin has been also involved in several forms of muscle wasting in adulthood …

Myostatin is hypothesized to regulate skeletal muscle mass and to be a potential target for
therapeutic intervention in sarcopenia. To clarify whether myostatin is invariably associated …

Myostatin inhibits myogenesis. Therefore, we sought to determine if mice lacking the
myostatin gene [Mstn (-/-)] would lose less muscle mass than wild-type mice during 7 days of …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin is a cytokine that has recently been shown to selectively and potently inhibit
myogenesis. To investigate the mechanisms of anabolic actions of GH on skeletal muscle …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …