Clostridium difficile infection: monoclonal or polyclonal genesis?

M Hell, M Permoser, G Chmelizek, JM Kern, M Maass… - Infection, 2011 - Springer
Clostridium difficile is considered to be a leading cause of hospital-acquired diarrhea. C.
difficile (CDI) infection shows a high rate of recurrence. There would have to be a …

Coexistence of multiple PCR-ribotype strains of Clostridium difficile in faecal samples limits epidemiological studies

RJ Van Den Berg, HAA Ameen… - Journal of medical …, 2005 - microbiologyresearch.org
Clostridium difficile is an important cause of antibiotic-associated diarrhoea. The
simultaneous presence of different strains in individual faecal samples has not yet been …

Clostridium difficile infection: early history, diagnosis and molecular strain typing methods

C Rodriguez, J Van Broeck, B Taminiau, M Delmée… - Microbial …, 2016 - Elsevier
Recognised as the leading cause of nosocomial antibiotic-associated diarrhoea, the
incidence of Clostridium difficile infection (CDI) remains high despite efforts to improve …

Clostridium difficile rates in asymptomatic and symptomatic hospitalized patients using nucleic acid testing

C Truong, LF Schroeder, R Gaur, VE Anikst… - … and infectious disease, 2017 - Elsevier
Abstract Background The Clostridium difficile rate in symptomatic patients represents both
those with C. difficile infection (CDI) and those with colonization. To predict the extent of CDI …

Clostridium difficile—a continually evolving and problematic pathogen

LF Dawson, E Valiente, BW Wren - Infection, Genetics and Evolution, 2009 - Elsevier
Clostridium difficile is a unique pathogen that often predominates in the bowel microflora as
a result of the microbial compositional changes following antibiotic treatment. The hospital …

Molecular epidemiology of Clostridium difficile infection in a major chinese hospital: an underrecognized problem in Asia?

PM Hawkey, C Marriott, WE Liu, ZJ Jian… - Journal of clinical …, 2013 - Am Soc Microbiol
Clostridium difficile infection is almost unrecognized in mainland China. We have
undertaken a study in a large Chinese teaching hospital in Changsha, Hunan, China, to …

Wide Diversity Of Clostridium Difficile Types At A Tertiary Referral Hospital

MH Samore, KM Bettin, PC DeGirolami… - Journal of Infectious …, 1994 - academic.oup.com
Nosocomial Clostridium difficile infection was investigated at a hospital with 15 cases of C.
difficile diarrhea per 1000 discharges. From January 1991 to May 1991, patients admitted or …

Molecular epidemiology of endemic Clostridium difficile infection

WN Fawley, MH Wilcox - Epidemiology & Infection, 2001 - cambridge.org
This is the first study to provide a comprehensive insight into the molecular epidemiology of
endemic Clostridium difficile and particularly that associated with a recently recognized …

Molecular Analysis of Clostridium difficile Strains Isolated from 18 Cases of Recurrent Clostridium difficile-Associated Diarrhea

Y Tang-Feldman, S Mayo, J Silva Jr… - Journal of clinical …, 2003 - Am Soc Microbiol
Recurrence of Clostridium difficile-associated diarrhea (CDAD) occurs in 15 to 20% of
patients after discontinuation of treatment. Arbitrarily primed PCR was used to investigate …

Epidemiology and Molecular Characterization of Clostridium difficile Strains from Patients with Diarrhea: Low Disease Incidence and Evidence of Limited Cross …

B Svenungsson, LG Burman… - Journal of Clinical …, 2003 - Am Soc Microbiol
We prospectively studied the epidemiology of Clostridium difficile-associated diarrhea
(CDAD) in a 900-bed hospital over the course of 12 months by PCR-ribotyping of C. difficile …