… of a patient to an inhaled corticosteroid depends on a number of … to the relative efficacy and
safety of inhaled corticosteroids, … It is important that safety and efficacy are investigated in the …

… In conclusion, the steroid reduction model to investigate bioequivalence or relative
potency of inhaled steroids can be successful, but is difficult. Determining the optimum design …

Background Inhaled corticosteroids (ICSs) are recommended as first-line controller medications
for persistent asthma. However, guidelines on the initial ICS doses, step-up and step-…

… studies assessed the safety of inhaled corticosteroid treatment in patients … inhaled
corticosteroids experienced significantly fewer exacerbations than patients taking placebo (relative …

… inhaled corticosteroids. A comparison needs to be made in terms of … Relative potency of
inhaled corticosteroids … A comparison of the efficacy and safety of inhaled corticosteroids in …

… inhaled corticosteroids work in asthma, and much more data on the efficacy and safety of
inhaled corticosteroids … different inhaled corticosteroids, so that inhaled corticosteroids are now …

… efficacy and safety of inhaled corticosteroids and comparing the properties of the various
drug/inhaler … (eg, its output, particle size distribution, efficiency of lung delivery, and ease of use)…

… Relative receptor affinity The receptor affinity of inhaled corticosteroids can be expressed
relative to that of the standard, dexamethasone (relative receptor affinity (RRA) = 100). Of the …

… Since the pharmacodynamics of each inhaled CS depends only on the drug's relative GR
binding affinity, and because this difference in affinity can be controlled by dose adjustments, …

… determine the relative clinical efficacy and pharmacokinetic … therapeutic index of the inhaled
corticosteroids. Secondary … asthma control or improved safety over older MDIs. All of the …