… will be discussed in detail to help define a model for further clinical trials on severe sepsis. …
in the design of severe sepsis trials and review several unsuccessful sepsis trials. Additionally…

… pathophysiology of sepsis, … clinical practice in the management of septic patients. Some
lessons from the past and insights into future needs for improved clinical trial design for sepsis …

… ) and the results of clinical trials showing immune and hemodynamic benefits, … of severe
sepsis. From the 1950s to the 1980s, high-dose steroids were used in the management of sepsis…

… unmet medical need in clinical trial design in sepsis studies. The use of … severe sepsis (PROWESS)
study group. Efficacy and safety of recombinant activated protein C for severe sepsis…

… for trial design. Most of our current approach to clinical trial design and reporting in severe
sepsis and acute lung … from previous trials. This manuscript discusses criteria for proceeding to …

… identifying effective therapies in clinical trials is that subgroups of patients at different likelihood
of benefit from disease-modifying therapy (eg, those with mild vs. severe sepsis) end up …

… Our study was designed as a prospective, randomized, double-blind, … this study and previous
clinical trials, we defined criteria for the presumptive diagnosis of severe sepsis and septic …

… At the end of 1998 we designed a study to compare two opposite approaches in providing
nutritional support to critical patient. The first approach (PN) gives the maximum priority to …

… of a separate article with a detailed analysis of similarities and differences between antithrombin
III and recombinant human activated protein C and the design of these 2 clinical trials. …

… patient outcomes and its design to predict severe sepsis up to 4 hours in advance.11
Predictions made by the MLA in this study likely also influenced the septic shock counts observed …