Therapeutic approaches to innate immunity: severe sepsis and septic shock

E Lolis, R Bucala - Nature reviews Drug discovery, 2003 - nature.com
therapeutic treatments for sepsis and its related conditions, activated protein C was recently
approved for the treatment of severe sepsis. … they are a mainstay of therapy for many different …

A new therapeutic approach for the treatment of sepsis

AB Iskit, MO Guc - Medical hypotheses, 2004 - Elsevier
… the different phases of septic shock, at least … septic shock combined with the blockade of
endothelin receptors at later stages appear feasible and a novel strategy for the therapy of septic

Management of severe sepsis: advances, challenges, and current status

I Martin-Loeches, MM Levy, A Artigas - … , development and therapy, 2015 - Taylor & Francis
septic shock in more than 1,000 patients with severe sepsis, … and any other combination
therapy possibilities (non-DCCT). … in patients with severe sepsis is one approach. De-escalation…

Experimental therapeutic strategies for severe sepsis: mediators and mechanisms

WR Parrish, M Gallowitsch‐Puerta… - Annals of the New …, 2008 - Wiley Online Library
Severe sepsis is the leading cause of mortality in intensive care units. The limited ability of
current therapies to reduce sepsis … effective therapeutic approaches for the treatment of sepsis

Sepsis and septic shock: current approaches to management

K Thompson, B Venkatesh, S Finfer - Internal Medicine Journal, 2019 - Wiley Online Library
… Thus, the old ‘severe sepsis’ becomes ‘sepsis’ with the new … The most severe form of sepsis
is septic shock, a state of … therapy,60-63 improve outcomes for patients with septic shock. …

Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches

S Esposito, G De Simone, G Boccia, F De Caro… - Journal of global …, 2017 - Elsevier
… They expanded the list of diagnostic criteria but the current concepts of sepsis, severe sepsis
and septic shock were only slightly revised and they remained the basis for clinical practice …

A rational approach to fluid therapy in sepsis

P Marik, R Bellomo - BJA: British Journal of Anaesthesia, 2016 - academic.oup.com
… considered vasodilator therapy, in patients with sepsis and … of patients with severe sepsis
and septic shock are not fluid … ’ of patients with severe sepsis and septic shock needs to be …

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

RS Hotchkiss, G Monneret, D Payen - The Lancet infectious diseases, 2013 - thelancet.com
… (A) Although both proinflammatory and anti-inflammatory responses begin rapidly after
sepsis, the initial response in previously healthy patients with severe sepsis is typified by an …

Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity

EP Rivers, L McIntyre, DC Morro, KK Rivers - Cmaj, 2005 - Can Med Assoc
… shock has led to the development of new therapies that place importance on early …
emphasizes approaches to the early recognition, diagnosis and therapeutic management of sepsis, …

Is neuroimmunomodulation a future therapeutic approach for sepsis?

V Kumar, A Sharma - International immunopharmacology, 2010 - Elsevier
… However, treatment of patients suffering from sepsis or its more severe form (ie severe
sepsis or septic shock) with available antibiotics or immunomodulatory agents did not prove …