… of sepsis immune pathophysiology, to update the choice of therapeutic approaches targeting
… , which enrolled more than thousand severe sepsis and septic shock patients, it was shown …

… treatment approach to sepsis remains to be defined by future clinical investigations. … of
severe sepsis and describe the current status of implementation of this knowledge into therapeutic …

… , sepsis and severe sepsis occur in 30% and 37% of the patients[1]. Gaieski and colleagues
designate severe sepsis … So far, therapeutic approaches are limited to fluid administration, …

… diagnostic and therapeutic approach to patients with sepsis, severe sepsis, and septic shock
in … and management of patients with severe sepsis and septic shock (SS/SS) as opposed to …

… septic shock requires the removal or inhibition of several toxins or substances activating the
cascade systems. A broader therapeutic approach … narrow therapeutic approaches which …

… Several new approaches have been reported to reduce mortality rates in severe sepsis. …
In addition, we experimentally investigated several new therapeutic targets such as 5-HT7 …

… Only one of these has been licensed as a therapy for sepsis—… efficacy in patients with severe
sepsis and septic shock and so, … , is novel therapies that target putative mediators of sepsis. …

… nature of sepsis, guiding toward new definition and novel therapeutic approaches. Diverse
… In a latest global survey of pediatric sepsis, severe sepsis remains a leading cause of death …

… humans, but clinical interventions such as antibiotic therapy and fluid resuscitation make the
… in organs as sepsis progresses to ‘severe sepsis’ and development of septic shock and multi…

… approach to sepsis began when a prospective randomized trial compared early goal-directed
therapy … metabolic demands for patients with severe sepsis in the intensive care unit (ICU). …